Stabilized Solutions of Bromonitromethane and Their Use as Biocides

Stable solutions of bromonitromethane are prepared and shown to be useful as an antimicrobial in a broad spectrum of applications. Bromonitromethane is applied using a stable aqueous solution or is generated from products which act as bromonitromethane donors. Bromonitromethane solutions are stabilized by the addition of a mineral acid.

Stabilized Solutions of Bromonitromethane and Their Use as Biocides, E. J. Termine, A. W. Dallmier, and A. M. Yeoman, United States Patent No. 5,866,511.
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Nonoxidizing antimicrobials are useful in many industrial systems including water systems, pulp and paper manufacturing, metal working fluid preservation, latex paint preservation, wood preservation, cosmetics preservation, and oil field and institutional hard-surface disinfection. However, despite the many commercially available nonoxidizing antimicrobials, none are entirely suitable for every application due to issues relating to efficacy, safety, environmental acceptability and cost.

Compounds containing gem bromonitro functionality have been shown to possess antimicrobial activity. The simplest of those compounds, bromonitromethane is reported to possess antimicrobial activity, but is also known to be unstable and unsuitable for commercial use. For example, Clark et al., in “Synthesis and Antimicrobial Activity of Aliphatic Nitro Compounds” state: “Bromonitromethane . . . inhibited all the organisms . . . but gave inconsistent results. This was attributed to the volatility of the compound, and it was not tested further.” See, Clark et al., 17 J. Med. Chem. 977-81 (1974).

It can be seen from the above that the prior art has failed to develop practical application technology for the use of bromonitromethane as an effective industrial nonoxidizing biocide. A need therefore exists for stable solutions of bromonitromethane that can be used as antimicrobial agents against a broad spectrum of bacteria, algae and fungi. The present invention addresses that need.


The present invention provides stable, biocidally effective solutions of bromonitromethane by providing the bromonitromethane in a solution stabilized by the addition of mineral acid. The stable, acidified solutions of bromonitromethane are effective as a broad spectrum industrial antimicrobial agent, and can be used in water treatment, paint, pulp and paper manufacturing, metal working fluids, and other nonoxidizing biocide applications. Acidified solutions of bromonitromethane are effective against a wide spectrum of bacteria, algae, and fungi.

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Dr. Enrico J. Termine is a senior executive and scientist with thirty years of experience in business leadership, research & development, product engineering, marketing, and manufacturing. He has consulted for a variety of industrial and legal clients on engagements involving valuations, due diligence assignments, market research reports, strategy development reports, science and technology assessments, and root cause investigations. Dr. Termine is a bromine chemistry expert. He specializes in oilfield applications, flame retardant plastics, industrial and recreational water treatment and disinfection, specialty and fine chemicals, polymer additives, plastics, and organic synthesis for life science molecules and advanced materials. Dr. Termine earned both his Bachelor of Science in Chemistry and his Ph.D. in Organic Chemistry from the University of Miami. He has collaborated on more than 38 patents and publications. His technical contributions are useful in consumer electronics; for petroleum and petrochemical processing; in transportation and industrial products; in healthcare; for industrial and household disinfection; and in building and construction materials.

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